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Article

Heterogeneity of IKZF1 genomic alterations and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia.

Leukemia - 1 Jul 2025

Wang'ondu Ruth W, Ashcraft Emily, Chang Ti-Cheng, Roberts Kathryn G, Brady Samuel W, Fan Yiping, Evans William, Relling Mary V, Crews Kristine R, Yang Jun, Yang Wenjian, Pounds Stanley, Wu Gang, Devidas Meenakshi, Maloney Kelly, Mattano Leonard, Schore Reuven J, Angiolillo Anne, Larsen Eric, Salzer Wanda, Burke Michael J, Loh Mignon L, Jeha Sima, Pui Ching-Hon, Inaba Hiroto, Cheng Cheng, Mullighan Charles G

Abstract excerpt

Genomic alterations of IKZF1 are common and associated with adverse clinical features in B-progenitor acute lymphoblastic leukemia (B-ALL). The relationship between the type of IKZF1 alteration, B-ALL genomic subtype and outcome are incompletely understood. B-ALL subtype and genomic alterations were determined using transcriptome and genomic sequencing, and SNP microarray analysis in 688 pediatric patients with...

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Identifiers

PMID: 40360879
DOI: 10.1038/s41375-025-02633-3
PMCID: PMC12759290

Genes

IKZF1
ABL1
BCR
CRLF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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