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Article

A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation.

Journal of autoimmunity - 1 May 2015

Anderson Ana C, Sullivan Jenna M, Tan Dewar J, Lee David H, Kuchroo Vijay K

Abstract excerpt

Genetic variants in il2 and il2ra have been associated with autoimmune disease susceptibility in both genome-wide association studies (GWAS) in humans and in genetic linkage studies in experimental models of autoimmunity. Specifically, genetic variants resulting in a low IL-2 phenotype are susceptibility alleles while variants resulting in a high IL-2 phenotype are resistance alleles. The association of high IL-2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25725581
DOI: 10.1016/j.jaut.2015.02.001
PMCID: PMC4414806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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