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Article

Conscientiousness is modified by genetic variation in catechol-O-methyltransferase to reduce symptom complaints in IBS patients.

Brain and behavior - 1 Jan 2015

Hall Kathryn T, Tolkin Benjamin R, Chinn Garrett M, Kirsch Irving, Kelley John M, Lembo Anthony J, Kaptchuk Ted J, Kokkotou Efi, Davis Roger B, Conboy Lisa A

Abstract excerpt

BACKGROUND: Attention to and perception of physical sensations and somatic states can significantly influence reporting of complaints and symptoms in the context of clinical care and randomized trials. Although anxiety and high neuroticism are known to increase the frequency and severity of complaints, it is not known if other personality dimensions or genes associated with cognitive function or sympathetic tone...

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Share to Anxiety
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COMT gene

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Source

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Identifiers

PMID: 25722948
DOI: 10.1002/brb3.294
PMCID: PMC4321393

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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