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The genetics of neuroticism: Insights from the Maudsley rat model and human studies

1 Jan 2023

Abstract excerpt

Abstract We examine some of the genetic features of neuroticism (N) taking as an animal model the Maudsley Reactive (MR) and Maudsley Nonreactive (MNR) rat strains which were selectively bred, respectively, for high and low open-field defecation (OFD) starting in the late 1950s. To draw analogies with human genetic studies, we explore the genetic correlation of N with irritable bowel syndrome (IBS). We review...

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PMID: 38107782
DOI: 10.1017/pen.2023.4

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