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Article

Transcriptional consequences of XPA disruption in human cell lines.

DNA repair - 1 Sept 2017

Manandhar Mandira, Lowery Megan G, Boulware Karen S, Lin Kevin H, Lu Yue, Wood Richard D

Abstract excerpt

Nucleotide excision repair (NER) in mammalian cells requires the xeroderma pigmentosum group A protein (XPA) as a core factor. Remarkably, XPA and other NER proteins have been detected by chromatin immunoprecipitation at some active promoters, and NER deficiency is reported to influence the activated transcription of selected genes. However, the global influence of XPA on transcription in human cells has not been...

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Identifiers

PMID: 28704716
DOI: 10.1016/j.dnarep.2017.06.028
PMCID: PMC5731452

Genes

XPA

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