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Article

BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints.

Developmental biology - 15 Apr 2015

Agarwal Shailesh, Loder Shawn J, Brownley Cameron, Eboda Oluwatobi, Peterson Jonathan R, Hayano Satoru, Wu Bingrou, Zhao Bin, Kaartinen Vesa, Wong Victor C, Mishina Yuji, Levi Benjamin

Abstract excerpt

BMP signaling mediated by ACVR1 plays a critical role for development of multiple structures including the cardiovascular and skeletal systems. While deficient ACVR1 signaling impairs normal embryonic development, hyperactive ACVR1 function (R206H in humans and Q207D mutation in mice, ca-ACVR1) results in formation of heterotopic ossification (HO). We developed a mouse line, which conditionally expresses ca-ACVR1...

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Share to Activin Receptors, Type I
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NFATC Transcription Factors

Share to Ossification, Heterotopic

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Source

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Identifiers

PMID: 25722188
DOI: 10.1016/j.ydbio.2015.02.011
PMCID: PMC4397658

Genes

ACVR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints.PMID 25722188Read ↗

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