Article
Distinct conditions support a novel classification for bradykinin-mediated angio-oedema.
Dermatology (Basel, Switzerland) - 1 Jan 2015
Dessart Panteha, Defendi Federica, Humeau Hélène, Nicolie Brigitte, Sarre Marie-Elodie, Charignon Delphine, Ponard Denise, Cichon Sven, Drouet Christian, Martin Ludovic
Abstract excerpt
BACKGROUND: Angio-oedema (AO) can be attributable to bradykinin (BK) accumulation, as is the case for prototypical hereditary AO (HAO) due to C1 inhibitor (C1-INH) deficiency. However, our clinical experience in a reference centre has shown that some patients display a clinical history suggestive of HAO, but exhibit normal C1-INH function, have no mutation in the causative genes associated with HAO (SERPING1,...
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