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Article

Depletion of the IKBKAP ortholog in zebrafish leads to hirschsprung disease-like phenotype.

World journal of gastroenterology - 21 Feb 2015

Cheng William Wai-Chun, Tang Clara Sze-Man, Gui Hong-Sheng, So Man-Ting, Lui Vincent Chi-Hang, Tam Paul Kwong-Hang, Garcia-Barcelo Maria-Mercè

Abstract excerpt

AIM: To investigate the role of IKBKAP (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein) in the development of enteric nervous system (ENS) and Hirschsprung disease (HSCR). METHODS: In this study, we injected a morpholino that blocked the translation of ikbkap protein to 1-cell stage zebrafish embryos. The phenotype in the ENS was analysed by antibody staining of...

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Identifiers

PMID: 25717236
DOI: 10.3748/wjg.v21.i7.2040
PMCID: PMC4326138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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