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Article

Expression level of Hand2 affects specification of enteric neurons and gastrointestinal function in mice.

Gastroenterology - 1 Aug 2011

D'Autréaux Fabien, Margolis Kara G, Roberts Jane, Stevanovic Korey, Mawe Gary, Li Zhishan, Karamooz Nima, Ahuja Ankur, Morikawa Yuka, Cserjesi Peter, Setlick Wanda, Gershon Michael D

Abstract excerpt

BACKGROUND & AIMS: Hand2 is a basic helix-loop-helix transcription factor required for terminal differentiation of enteric neurons. We studied Hand2 haploinsufficient mice, to determine whether reduced expression of Hand2 allows sufficient enteric neurogenesis for survival, but not for development of a normal enteric nervous system (ENS). METHODS: Enteric transcripts that encode Hand2 and the neuron-specific...

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Identifiers

PMID: 21669203
DOI: 10.1053/j.gastro.2011.04.059
PMCID: PMC3152642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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