Article
Mutations of HNRNPA0 and WIF1 predispose members of a large family to multiple cancers.
Familial cancer - 1 Jun 2015
Wei Chongjuan, Peng Bo, Han Younghun, Chen Wei V, Rother Joshua, Tomlinson Gail E, Boland C Richard, Chaussabel Damien, Chaussabel Marc, Frazier Marsha L, Amos Christopher I
Abstract excerpt
We studied a large family that presented a strong familial susceptibility to multiple early onset cancers including prostate, breast, colon, and several other uncommon cancers. Through targeted gene, linkage, and whole genome sequencing analyses, we show that the presence of a variant in the regulatory region of HNRNPA0 associated with elevated cancer incidence in this family (Hazard ratio = 7.20, p = 0.0004)....
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