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Article

Impact of Enhanced Production of Endogenous Heme Oxygenase-1 by Pitavastatin on Survival and Functional Activities of Bone Marrow-derived Mesenchymal Stem Cells.

Journal of cardiovascular pharmacology - 1 Jun 2015

Kawashiri Masa-Aki, Nakanishi Chiaki, Tsubokawa Toshinari, Shimojima Masaya, Yoshida Shohei, Yoshimuta Tsuyoshi, Konno Tetsuo, Yamagishi Masakazu, Hayashi Kenshi

Abstract excerpt

Although mesenchymal stem cells (MSCs) have a therapeutic potential for the repair of tissue injuries, their poor viability in damaged tissue limits their effectiveness. Statins can induce an increased production of heme oxygenase-1 (HO-1), which may prevent this detrimental effect in MSCs. We investigated the protective effect of statin-induced overexpression of HO-1 by examining changes in gene expression and...

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Share to Enzyme Induction
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neovascularization, Physiologic

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Identifiers

PMID: 25714596
DOI: 10.1097/FJC.0000000000000231
PMCID: PMC4461382

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