Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of anti-apoptotic and anti-oxidative effects of bone marrow mesenchymal stem cells with transient overexpression of heme oxygenase-1 on myocardial ischemia.

American journal of physiology. Heart and circulatory physiology - 1 May 2010

Tsubokawa Toshinari, Yagi Kunimasa, Nakanishi Chiaki, Zuka Masahiko, Nohara Atsushi, Ino Hidekazu, Fujino Noboru, Konno Tetsuo, Kawashiri Masa-aki, Ishibashi-Ueda Hatsue, Nagaya Noritoshi, Yamagishi Masakazu

Abstract excerpt

Although mesenchymal stem cells (MSCs) have therapeutic potential for tissue injury, intolerance and poor cell viability limit their reparative capability. Therefore, we examined the impact of bone marrow-derived MSCs, in which heme oxygenase-1 (HO-1) was transiently overexpressed, on the repair of an ischemic myocardial injury. When MSCs and HO-1-overexpressed MSCs (MSC(HO-1)) were exposed to serum...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Transplantation
Share to Capillaries

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Culture Media, Serum-Free

Share to Heme Oxygenase-1

Share to Mesenchymal Stem Cell Transplantation

Share to Myocardial Ischemia

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Rats, Inbred Lew

Source

Identifiers

PMID: 20154257
DOI: 10.1152/ajpheart.01330.2008

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of anti-apoptotic and anti-oxidative effects of bone marrow mesenchymal stem cells with transient overexpression of heme oxygenase-1 on myocardial ischemia.PMID 20154257Read ↗

Impact of Enhanced Production of Endogenous Heme Oxygenase-1 by Pitavastatin on Survival and Functional Activities of Bone Marrow-derived Mesenchymal Stem Cells.Semantic proximity Read ↗

Adenovirus-mediated expression of the HO-1 protein within MSCs decreased cytotoxicity and inhibited apoptosis induced by oxidative stressesSemantic proximity Read ↗

HO-1 modified mesenchymal stem cells modulate MMPs/TIMPs system and adverse remodeling in infarcted myocardium.Semantic proximity Read ↗

Murine Bone Marrow Mesenchymal Stromal Cells Respond Efficiently to Oxidative Stress Despite the Low Level of Heme Oxygenases 1 and 2.Semantic proximity Read ↗

Genetically Engineered Mesenchymal Stem Cells Influence Gene Expression in Donor Cardiomyocytes and the Recipient HeartSemantic proximity Read ↗

PEP-1-CAT-transduced mesenchymal stem cells acquire an enhanced viability and promote ischemia-induced angiogenesis.Semantic proximity Read ↗

Bone marrow mesenchymal stem cells transfer in patients with ST-segment elevation myocardial infarction: single-blind, multicentre, randomized controlled trialSemantic proximity Read ↗

Hypoxia-inducible plasmid expressing both miSHP-1 and HO-1 for the treatment of ischemic diseaseSemantic proximity Read ↗

Permanently Hypoxic Cell Culture Yields Rat Bone Marrow Mesenchymal Cells with Higher Therapeutic Potential in the Treatment of Chronic Myocardial Infarction.Semantic proximity Read ↗

Overexpression of MicroRNA-1 improves the efficacy of mesenchymal stem cell transplantation after myocardial infarction.Semantic proximity Read ↗

Conditioned medium harvested from Hif1α engineered mesenchymal stem cells ameliorates LAD-occlusion -induced injury in rat acute myocardial ischemia model.Semantic proximity Read ↗

Intramyocardial injection of hypoxia-preconditioned adipose-derived stromal cells treats acute myocardial infarction: an in vivo study in swine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.