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Article

SC79 rescues osteoblasts from dexamethasone though activating Akt-Nrf2 signaling.

Biochemical and biophysical research communications - 7 Oct 2016

Li Song-Tao, Chen Nan-Nan, Qiao Yin-Biao, Zhu Wei-Li, Ruan Jian-Wei, Zhou Xiao-Zhong

Abstract excerpt

Dexamethasone (Dex) causes osteoblast cell injuries. In the present research, we tested the potential effect of SC79, a novel and specific Akt activator, against Dex in osteoblasts. In primary murine osteoblasts and osteoblastic MC3T3-E1 cells, pretreatment with SC79 significantly attenuated Dex-induced cell death. Further, Dex-induced mitochondrial permeability transition pore (mPTP) opening, cytochrome C...

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Identifiers

PMID: 27614310
DOI: 10.1016/j.bbrc.2016.09.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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