Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia Promotes Osteogenesis of Human Placental-Derived Mesenchymal Stem Cells.

The Tohoku journal of experimental medicine - 1 Aug 2016

Gu Qiaoli, Gu Yanzheng, Shi Qin, Yang Huilin

Abstract excerpt

Placental-derived mesenchymal stem cells (pMSCs) are promising candidates for regenerative medicine because they possess high proliferative capacity and multi-differentiation potential. Human pMSCs are residing in an environment with low oxygen tension in the body. Heme oxygenase-1 (HO-1) is known to participate in the regulation of MSC differentiation. The present study aimed to investigate the impact of hypoxia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Hypoxia
Share to Cell Proliferation
Share to Cell Shape

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heme Oxygenase-1

Share to Mesenchymal Stem Cells

Share to Osteogenesis

Share to Placenta

Share to Stem Cell Factor

Source

Identifiers

PMID: 27477937
DOI: 10.1620/tjem.239.287

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia Promotes Osteogenesis of Human Placental-Derived Mesenchymal Stem Cells.PMID 27477937Read ↗

Current View on Osteogenic Differentiation Potential of Mesenchymal Stromal Cells Derived from Placental TissuesSemantic proximity Read ↗

Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner.Semantic proximity Read ↗

Differential effects of hypoxia on osteochondrogenic potential of human adipose-derived stem cells.Semantic proximity Read ↗

Hypoxia-inducible factor-2 alpha promotes the proliferation of human placenta-derived mesenchymal stem cells through the MAPK/ERK signaling pathwaySemantic proximity Read ↗

Long non-coding RNA SNHG16 promotes human placenta-derived mesenchymal stem cell proliferation capacity through the PI3K/AKT pathway under hypoxiaSemantic proximity Read ↗

Increased Proliferation and Analysis of Differential Gene Expression in Human Wharton's Jelly-derived Mesenchymal Stromal Cells under HypoxiaSemantic proximity Read ↗

Hypoxic downregulation of cellular proliferation and loss of phenotype stability in human osteoblasts is mediated by HIF-1α.Semantic proximity Read ↗

HMOX1 is partly responsible for phenotypic and functional abnormalities in mesenchymal stem cells/stromal cells from placenta of preeclampsia (PE) patients.Semantic proximity Read ↗

The hypoxic microenvironment: a driving force for heterotopic ossification progressionSemantic proximity Read ↗

Characterization of MSCs from human placental decidua basalis in hypoxia and serum deprivation.Semantic proximity Read ↗

Modulation of physical environment makes placental mesenchymal stromal cells suitable for therapy.Semantic proximity Read ↗

Human umbilical cord mesenchymal stem cells restores mTOR-mediated autophagy homeostasis to alleviate placental injury and improve pregnancy outcomes in preeclampsiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.