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Decreasing <i>pfmdr1</i> Copy Number Suggests that Plasmodium falciparum in Western Cambodia Is Regaining <i>In Vitro</i> Susceptibility to Mefloquine

26 Feb 2015

Abstract excerpt

Dihydroartemisinin-piperaquine is the current frontline artemisinin combination therapy (ACT) for Plasmodium falciparum malaria in Cambodia but is now failing in several western provinces. To investigate artesunate plus mefloquine (AS+MQ) as a replacement ACT, we measured the prevalence of multiple pfmdr1 copies--a molecular marker for MQ resistance--in 844 P. falciparum clinical isolates collected in 2008 to...

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PMID: 25712365
DOI: 10.1128/aac.05163-14

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