Article
Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia.
Malaria journal - 12 Jan 2009
Lim Pharath, Alker Alisa P, Khim Nimol, Shah Naman K, Incardona Sandra, Doung Socheat, Yi Poravuth, Bouth Denis Mey, Bouchier Christiane, Puijalon Odile Mercereau, Meshnick Steven R, Wongsrichanalai Chansuda, Fandeur Thierry, Le Bras Jacques, Ringwald Pascal, Ariey Frédéric
Abstract excerpt
BACKGROUND: The combination of artesunate and mefloquine was introduced as the national first-line treatment for Plasmodium falciparum malaria in Cambodia in 2000. However, recent clinical trials performed at the Thai-Cambodian border have pointed to the declining efficacy of both artesunate-mefloquine and artemether-lumefantrine. Since pfmdr1 modulates susceptibility to mefloquine and artemisinin derivatives,...
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