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Article

Human neural stem cell-derived cultures in three-dimensional substrates form spontaneously functional neuronal networks.

Journal of tissue engineering and regenerative medicine - 1 Apr 2017

Smith Imogen, Silveirinha Vasco, Stein Jason L, de la Torre-Ubieta Luis, Farrimond Jonathan A, Williamson Elizabeth M, Whalley Benjamin J

Abstract excerpt

Differentiated human neural stem cells were cultured in an inert three-dimensional (3D) scaffold and, unlike two-dimensional (2D) but otherwise comparable monolayer cultures, formed spontaneously active, functional neuronal networks that responded reproducibly and predictably to conventional pharmacological treatments to reveal functional, glutamatergic synapses. Immunocytochemical and electron microscopy...

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PMID: 25712225
DOI: 10.1002/term.2001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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