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Article

Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum.

Nucleic acids research - 11 Mar 2015

Genois Marie-Michelle, Plourde Marie, Éthier Chantal, Roy Gaétan, Poirier Guy G, Ouellette Marc, Masson Jean-Yves

Abstract excerpt

To achieve drug resistance Leishmania parasite alters gene copy number by using its repeated sequences widely distributed through the genome. Even though homologous recombination (HR) is ascribed to maintain genome stability, this eukaryote exploits this potent mechanism driven by the Rad51 recombinase to form beneficial extrachromosomal circular amplicons. Here, we provide insights on the formation of these...

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Identifiers

PMID: 25712090
DOI: 10.1093/nar/gkv118
PMCID: PMC4357719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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