Chronological Age Interacts with the Circadian Melatonin Receptor 1B Gene Variation, Determining Fasting Glucose Concentrations in Mediterranean Populations. Additional Analyses on Type-2 Diabetes Risk.

doi:10.3390/nu12113323

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Chronological Age Interacts with the Circadian Melatonin Receptor 1B Gene Variation, Determining Fasting Glucose Concentrations in Mediterranean Populations. Additional Analyses on Type-2 Diabetes Risk.

Nutrients - 29 Oct 2020

Sorlí Jose V, Barragán Rocío, Coltell Oscar, Portolés Olga, Pascual Eva C, Ortega-Azorín Carolina, González José I, Estruch Ramon, Saiz Carmen, Pérez-Fidalgo Alejandro, Ordovas Jose M, Corella Dolores

Abstract excerpt

Gene-age interactions have not been systematically investigated on metabolic phenotypes and this modulation will be key for a better understanding of the temporal regulation in nutrigenomics. Taking into account that aging is typically associated with both impairment of the circadian system and a decrease in melatonin secretion, we focused on the melatonin receptor 1B (MTNR1B)-rs10830963 C>G variant that has been...

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Identifiers

PMID: 33138317
DOI: 10.3390/nu12113323
PMCID: PMC7692445

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