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Article

Inhibition of canonical NF-κB nuclear localization by (-)-DHMEQ via impairment of DNA binding.

Oncology research - 1 Jan 2015

Horie Kana, Ma Jun, Umezawa Kazuo

Abstract excerpt

We previously discovered (-)-DHMEQ as a selective inhibitor of NF-κB, and it was shown to suppress many cancer and inflammation models in animals. (-)-DHMEQ directly binds to NF-κB components to inhibit DNA binding, and moreover, it often inhibits nuclear translocation of NF-κB. The mechanism of...

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Identifiers

PMID: 25706397
DOI: 10.3727/096504014X14146137738628
PMCID: PMC7838434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25706397-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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