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Article

Inhibition of nuclear import suppresses androgen receptor action and overcomes resistance in prostate cancer.

BMC cancer - 25 Feb 2026

Wang Xuan, Xu Xin, Fang Shengyun, Shi Xiaolei, Yang Yili

Abstract excerpt

BACKGROUND: Androgen deprivation and androgen receptor (AR) antagonists are essential treatments for prostate cancers in the clinic. However, after an initially effective response, most tumors become resistant to androgen deprivation therapies. Resistance often arises from AR mutations, resulting in ligand-independent activation and nuclear translocation of AR. METHODS: This study investigated the effects of...

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Identifiers

PMID: 41742135
DOI: 10.1186/s12885-026-15792-y
PMCID: PMC13040811

Genes

AR
KPNB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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