Article
Piperlongumine selectively suppresses ABC-DLBCL through inhibition of NF-κB p65 subunit nuclear import.
Biochemical and biophysical research communications - 10 Jul 2015
Niu Mingshan, Shen Yangling, Xu Xiaoyu, Yao Yao, Fu Chunling, Yan Zhiling, Wu Qingyun, Cao Jiang, Sang Wei, Zeng Lingyu, Li Zhenyu, Liu Xuejiao, Xu Kailin
Abstract excerpt
Constitutive NF-κB activation is required for survival of activated B cell-like subtype of diffuse large B cell lymphoma (ABC-DLBCL). However, current NF-κB targeting strategies lack cancer cell specificity. Here, we identified a novel inhibitor, piperlongumine, features direct binding to NF-κB p...
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