Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GISP increases neurotransmitter receptor stability by down-regulating ESCRT-mediated lysosomal degradation.

Neuroscience letters - 13 Mar 2009

Kantamneni Sriharsha, Holman David, Wilkinson Kevin A, Nishimune Atsushi, Henley Jeremy M

Abstract excerpt

GPCR interacting scaffold protein (GISP) is a multi-domain brain-specific scaffold protein that can regulate GABA(B) receptor complexes by both enhancing their surface expression and by inhibiting their lysosomal degradation. GISP retards degradation of GABA(B) receptors through its interaction with tumour susceptibility gene 101 (TSG101), a member of the endosomal sorting complex required for transport (ESCRT)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to A Kinase Anchor Proteins
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Endosomal Sorting Complexes Required for Transport

Share to Endosomes

Share to Lysosomes

Share to Receptors, GABA-B

Share to Receptors, Neurotransmitter

Source

Open in PubMed Open full text

Identifiers

PMID: 19154774
DOI: 10.1016/j.neulet.2009.01.011
PMCID: PMC3310152

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GISP increases neurotransmitter receptor stability by down-regulating ESCRT-mediated lysosomal degradation.PMID 19154774Read ↗

GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation.Semantic proximity Read ↗

Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1.Semantic proximity Read ↗

Somatostatin receptor subtype 1 is a PDZ ligand for synapse-associated protein 97 and a potential regulator of growth cone dynamics.Semantic proximity Read ↗

Diazepam Accelerates GABAAR Synaptic Exchange and Alters Intracellular TraffickingSemantic proximity Read ↗

Activity-dependent ubiquitination of GABA(A) receptors regulates their accumulation at synaptic sites.Semantic proximity Read ↗

[PRIP-1 involved in GABAA receptor trafficking].Semantic proximity Read ↗

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation.Semantic proximity Read ↗

Quantitative interactome proteomics identifies proteostasis network for GABA <sub>A</sub> receptorsSemantic proximity Read ↗

Constitutive traffic of melanocortin-4 receptor in Neuro2A cells and immortalized hypothalamic neurons.Semantic proximity Read ↗

GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABA A receptor trafficking and social behaviorSemantic proximity Read ↗

<i>Arfgef1</i> haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABA <sub>A</sub> receptorsSemantic proximity Read ↗

Proteasomal degradation of γ-aminobutyric acidB receptors is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and regulated by neuronal activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.