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Article

Epigenetic silencing of miR-708 enhances NF-κB signaling in chronic lymphocytic leukemia

20 Feb 2015

Abstract excerpt

MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression and their deregulation is involved in tumor development. Epigenetic gene silencing in cancer by DNA methylation contributes to the silencing of tumor-suppressor genes, including miRNAs. We have recently shown that the promoter of miR-708 is aberrantly methylated in chronic lymphocytic leukemia (CLL). To characterize the molecular signaling...

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PMID: 25704289
DOI: 10.1002/ijc.29491

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