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Article

Protease-mediated release of chemotherapeutics from mesoporous silica nanoparticles to ex vivo human and mouse lung tumors.

ACS nano - 24 Mar 2015

van Rijt Sabine H, Bölükbas Deniz A, Argyo Christian, Datz Stefan, Lindner Michael, Eickelberg Oliver, Königshoff Melanie, Bein Thomas, Meiners Silke

Abstract excerpt

Nanoparticles allow for controlled and targeted drug delivery to diseased tissues and therefore bypass systemic side effects. Spatiotemporal control of drug release can be achieved by nanocarriers that respond to elevated levels of disease-specific enzymes. For example, matrix metalloproteinase 9 (MMP9) is overexpressed in tumors, is known to enhance the metastatic potency of malignant cells, and has been...

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Identifiers

PMID: 25703655
DOI: 10.1021/nn5070343

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MMP9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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