Article
Assessment of Sunitinib-Induced Toxicities and Clinical Outcomes Based on Therapeutic Drug Monitoring of Sunitinib for Patients With Renal Cell Carcinoma.
Clinical genitourinary cancer - 1 Aug 2015
Noda Satoshi, Otsuji Takashi, Baba Masato, Yoshida Tetsuya, Kageyama Susumu, Okamoto Keisei, Okada Yusaku, Kawauchi Akihiro, Onishi Hiroyuki, Hira Daiki, Morita Shin-Ya, Terada Tomohiro
Abstract excerpt
BACKGROUND: Sunitinib has been approved for the treatment of metastatic renal cell carcinoma (RCC). Sunitinib pharmacokinetics shows a large interpatient variability. PATIENTS AND METHODS: A retrospective, observational clinical study of 21 patients with RCC was performed. Sunitinib was administered for 4 weeks of a 6-week cycle for the first cycle. We evaluated the association of sunitinib-induced toxicities and...
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