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DNA Methyl Transferase 1 Reduces Expression of SRD5A2 in the Aging Adult Prostate

17 Feb 2015

Abstract excerpt

5-α Reductase type 2 (SRD5A2) is a critical enzyme for prostatic development and growth. Inhibition of SRD5A2 by finasteride is used commonly for the management of urinary obstruction caused by benign prostatic hyperplasia. Contrary to common belief, we have found that expression of SRD5A2 is variable and absent in one third of benign adult prostates. In human samples, absent SRD5A2 expression is associated with...

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PMID: 25700986
DOI: 10.1016/j.ajpath.2014.11.020

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