Article

Promoter Hypermethylation and Androgen Receptor Regulation Unveil Dual Oxidase 1 as a Tumor Suppressor in Prostate Adenocarcinoma

2026-05-21

Abstract excerpt

<title>Abstract</title> <p>Promoter hypermethylation of tumor suppressor genes (TSGs) is a hallmark of prostate cancer (PCa) development and holds promise as a diagnostic and prognostic biomarker. Through global methylation analysis of benign prostatic hyperplasia and PCa tissue samples, we identified dual oxidase 1 (DUOX1), a member of the NADPH oxidase family, as a methylation-driven TSG involved in PCa progres...

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Literature Corpus work: d713a7c8-605f-53d0-9ab8-588a761194e4
DOI: 10.21203/rs.3.rs-9621447/v1

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