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Article

Cytologic atypia is predictive of increased risk of malignancy and BRAF mutations in thyroid follicular neoplasms (Bethesda category IV).

Journal of the American Society of Cytopathology - 1 Jan 2026

Dean Maureen A, Emiliani Francesco, Levy Joshua, Rodrigues Simoes Nathalie J, Coconubo Daniel Martinez, Gutmann Edward, Vaickus Louis, Marotti Jonathan, Kerr Darcy A, Liu Xiaoying

Abstract excerpt

INTRODUCTION: Molecular testing on thyroid fine needle aspirations with indeterminate cytology is integral to patient management. The aim of this study was to investigate the risk of malignancy in nodules diagnosed as Bethesda category IV, follicular neoplasm (FN), with and without cytologic atypia. MATERIALS AND METHODS: A total of 186 thyroid fine needle aspirations classified as Bethesda category IV (FN) were...

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Share to Adenocarcinoma, Follicular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biopsy, Fine-Needle

Share to Mutation

Share to Proto-Oncogene Proteins B-raf

Share to Thyroid Gland

Share to Thyroid Neoplasms

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Source

Identifiers

PMID: 40908238
DOI: 10.1016/j.jasc.2025.07.003

Genes

BRAF
ETV6
NTRK3
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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