Article
Left-sided early-onset vs late-onset colorectal carcinoma: histologic, clinical, and molecular differences.
American journal of clinical pathology - 1 Mar 2015
Pilozzi Emanuela, Maresca Carmen, Duranti Enrico, Giustiniani Maria Cristina, Catalanotto Caterina, Lucarelli Marco, Cogoni Carlo, Ferri Mario, Ruco Luigi, Zardo Giuseppe
Abstract excerpt
OBJECTIVES: Carcinomas of the left colon represent a neoplasm of older patients (late onset), but epidemiologic evidence has been showing an increasing incidence in patients 50 years or younger (early onset). In this study, we investigate pathologic and molecular features of early- and late-onset...
Topics
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Carcinoma
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- DNA, Neoplasm
- Education, Medical, Continuing
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry