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Article

Sporadic early-onset colorectal cancer is a specific sub-type of cancer: a morphological, molecular and genetics study.

PloS one - 1 Jan 2014

Kirzin Sylvain, Marisa Laetitia, Guimbaud Rosine, De Reynies Aurélien, Legrain Michèle, Laurent-Puig Pierre, Cordelier Pierre, Pradère Bernard, Bonnet Delphine, Meggetto Fabienne, Portier Guillaume, Brousset Pierre, Selves Janick

Abstract excerpt

Sporadic early onset colorectal carcinoma (EOCRC) which has by definition no identified hereditary predisposition is a growing problem that remains poorly understood. Molecular analysis could improve identification of distinct sub-types of colorectal cancers (CRC) with therapeutic implications and thus can help establish that sporadic EOCRC is a distinct entity. From 954 patients resected for CRC at our...

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Identifiers

PMID: 25083765
DOI: 10.1371/journal.pone.0103159
PMCID: PMC4118858

Genes

BRAF
EGFR
HGF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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