Article
High frequency of KRAS mutation in early onset colorectal adenocarcinoma: implications for pathogenesis.
Human pathology - 1 Oct 2016
Watson Rao, Liu Ta-Chiang, Ruzinova Marianna B
Abstract excerpt
While the incidence of sporadic early onset (defined here as ≤40 years of age) colorectal cancer is increasing, its molecular pathogenesis remains unclear. In particular, previous studies have suggested that the genetic initiating events in these patients may be distinct from those observed in ol...
Topics
- Adenocarcinoma
- Adolescent
- Adult
- Age of Onset
- Biomarkers, Tumor
- Cell Transformation, Neoplastic
- Colorectal Neoplasms
- DNA Mutational Analysis
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Male
- Mutation
- Neoplasm Grading
- Neoplasm Staging
- Phenotype
- Proto-Oncogene Proteins p21(ras)