Article
A single-nucleotide polymorphism in serine-threonine kinase 11, the gene encoding liver kinase B1, is a risk factor for multiple sclerosis.
ASN neuro - 1 Jan 2000
Boullerne Anne I, Skias Demetrios, Hartman Elizabeth M, Testai Fernando D, Kalinin Sergey, Polak Paul E, Feinstein Douglas L
Abstract excerpt
We identified a family in which five siblings were diagnosed with multiple sclerosis (MS) or clinically isolated syndrome. Several women in the maternal lineage have comorbidities typically associated with Peutz Jeghers Syndrome, a rare autosomal-dominant disease caused by mutations in the serine-threonine-kinase 11 (STK11) gene, which encodes liver kinase B1. Sequence analysis of DNA from one sibling identified...
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