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Article

DNA damage response markers are differentially expressed in BRCA-mutated breast cancers.

Breast cancer research and treatment - 1 Feb 2015

Aleskandarany Mohammed, Caracappa Daniela, Nolan Christopher C, Macmillan R Douglas, Ellis Ian O, Rakha Emad A, Green Andrew R

Abstract excerpt

Cells have stringent DNA repair pathways that are specific for each different set of DNA lesions which is accomplished through the integration of complex array of proteins. However, BRCA-mutated breast cancer (BC) has defective DNA repair mechanisms. This study aims to investigate differential expression of a large panel of DNA repair markers to characterise DNA repair mechanisms in BRCA-associated tumours...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25690937
DOI: 10.1007/s10549-015-3306-6
PMCID: PMC4344553

Genes

BRCA1
PARP1
BRCA2
RAD51
BARD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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