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An overview of the research progress of BRCA gene mutations in breast cancer.

Biochimica et biophysica acta. Reviews on cancer - 1 Jul 2023

Wan Andi, Zhang Guozhi, Ma Dandan, Zhang Yi, Qi Xiaowei

Abstract excerpt

The breast cancer susceptibility gene (BRCA) is an important tumor suppressor gene, including BRCA1 and BRCA2, a biomarker that assesses the risk of breast cancer and influences a patient's individualized treatment options. BRCA1/2 mutation (BRCAm) increases the risk of breast cancer. However, breast-conserving surgery is still an option for BRCAm, and prophylactic mastectomy and nipple-sparing mastectomy may...

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Identifiers

PMID: 37172654
DOI: 10.1016/j.bbcan.2023.188907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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