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Article

Enhanced serum proteolysis resistance of cell-penetrating peptides.

Therapeutic delivery - 1 Feb 2015

Fominaya Jesús, Bravo Jerónimo, Decaudin Didier, Brossa Jean Yves, Nemati Fariba, Rebollo Angelita

Abstract excerpt

AIM: Before starting preclinical studies, we have analyzed the integrity in serum of DPT-C9h, a promising therapeutic peptide, and performed modifications in order to improve its stability. MATERIALS & METHODS: Mutant peptides exchanging arginine 8 for either lysine, asparagine or alanine were synthesized and compared with the parental peptide. RESULTS: All mutants clearly improved peptide stability while keeping...

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Share to Amino Acid Sequence
Share to Breast Neoplasms
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Nude

Share to Proteolysis

Share to Sequence Analysis, Protein

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Share to Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 25690083
DOI: 10.4155/tde.14.100

Genes

DPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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