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Article

Triggering PIK3CA Mutations in PI3K/Akt/mTOR Axis: Exploration of Newer Inhibitors and Rational Preventive Strategies.

Current pharmaceutical design - 1 Jan 2016

Asati Vivek, Bharti Sanjay K, Mahapatra Debarshi Kar, Asati Vikas, Budhwani Ashok K

Abstract excerpt

BACKGROUND: PIK3CA gene was found in generation of p110 alpha (p110α) protein through an instruction process. p110 alpha acts as a catalytic subunit of phosphatidylinositol 3-kinase (PI3K) proceed phosphorylation of signal molecules through PI3K pathway. This PI3K involved in regulation of cellular growth, transformation, adhesion, apoptosis, survival and motility. In some situations the PI3K/Akt pathway get...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27296758
DOI: 10.2174/1381612822666160614000053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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