Article
Multiplex families with multiple system atrophy.
Archives of neurology - 1 Apr 2007
Hara Kenju, Momose Yoshio, Tokiguchi Susumu, Shimohata Mitsuteru, Terajima Kenshi, Onodera Osamu, Kakita Akiyoshi, Yamada Mitsunori, Takahashi Hitoshi, Hirasawa Motoyuki, Mizuno Yoshikuni, Ogata Katsuhisa, Goto Jun, Kanazawa Ichiro, Nishizawa Masatoyo, Tsuji Shoji
Abstract excerpt
BACKGROUND: Multiple system atrophy (MSA) has been considered a sporadic disease, without patterns of inheritance. OBJECTIVE: To describe the clinical features of 4 multiplex families with MSA, including clinical genetic aspects. DESIGN: Clinical and genetic study. SETTING: Four departments of neurology in Japan. Patients Eight patients in 4 families with parkinsonism, cerebellar ataxia, and autonomic failure...
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