Article
RB1 polymorphism contributes to the efficacy of platinum-taxanes in advanced squamous cell lung cancer.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2015
Liu Di, Xu Wen, Zhang Zhi-Wei, Qian Ji, Zheng Hui, Zhang Jie, Su Bo
Abstract excerpt
BACKGROUND: RB1 (retinoblastoma 1) was reportedly one of the major determinative factors for sensitivity to taxanes in previous studies. In this study, we investigated the influence of RB1 single nucleotide polymorphisms (SNPs) on the efficacy of platinum-taxane regimens in advanced NSCLC patients. MATERIALS AND METHODS: 234 cases of patients with advanced NSCLC who were treated with first-line platinum-taxane...
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