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Article

Association of Base Excision Repair Gene Polymorphisms with the Response to Chemotherapy in Advanced Non-Small Cell Lung Cancer.

Chinese medical journal - 20 Aug 2018

Dong Jie, Wang Xu, Yu Yu, Yan Xu, Cui Jiu-Wei

Abstract excerpt

BACKGROUND: Base excision repair (BER) plays an important role in the maintenance of genome integrity and anticancer drug resistance. This study aimed to explore the role of BER gene polymorphisms in response to chemotherapy for advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy. METHODS: During the period from November 2009 to January 2016, a total of 152 patients...

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Topics

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Share to Antineoplastic Agents
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to DNA Repair

Share to Lung Neoplasms

Share to Polymorphism, Genetic

Share to Polymorphism, Single Nucleotide

Share to X-ray Repair Cross Complementing Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 30082520
DOI: 10.4103/0366-6999.238141
PMCID: PMC6085862

Genes

MUTYH
PARP1
XRCC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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