Article
MMP2 gene-735 C/T and MMP9 gene -1562 C/T polymorphisms in JAK2V617F positive myeloproliferative disorders.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2015
Sag Sebnem Ozemri, Gorukmez Ozlem, Ture Mehmet, Gorukmez Orhan, Topak Ali, Sahinturk Serdar, Ocakoglu Gokhan, Gulten Tuna, Ali Ridvan, Yakut Tahsin
Abstract excerpt
BACKGROUND: Myeloproliferative disorders (MPDs) are clonal hematologic malignancies originating at the level of the pluripotent hematopoietic stem cell. Matrix metalloproteases (MMPs) are proteolytic enzymes that contribute to all stages of malignancy progression. Genetic variants in the MMP genes may influence the biological function of these enzymes and change their role in carcinogenesis and progression. To...
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