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Article

Role of the MDM2 promoter polymorphism (-309T>G) in acute myeloid leukemia development.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2015

Cingeetham Anuradha, Vuree Sugunakar, Jiwatani Sangeeta, Kagita Sailaja, Dunna Nageswara Rao, Meka Phanni Bhushann, Gorre Manjula, Annamaneni Sandhya, Digumarti Raghunadharao, Sinha Sudha, Satti Vishnupriya

Abstract excerpt

BACKGROUND: The human homologue of the mouse double minute 2 (MDM2) gene is a negative regulator of Tp53. MDM2-309T>G a functional promoter polymorphism was found to be associated with overexpression thereby attenuation of Tp53 stress response and increased cancer susceptibility. We have planned to evaluate the possible role of MDM2-309T>G polymorphism with risk and response to chemotherapy in AML. MATERIALS AND...

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Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease-Free Survival

Share to Leukemia, Myeloid, Acute

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins c-mdm2

Share to Tumor Suppressor Protein p53

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Source

Identifiers

PMID: 25854351
DOI: 10.7314/apjcp.2015.16.7.2707

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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