Article
The role of configuration and coupling in autoregulatory gene circuits.
Molecular microbiology - 1 Jan 2010
Wu Kang, Rao Christopher V
Abstract excerpt
Autoregulatory gene circuits can be physically encoded within the genome in a number of different configurations. By physical encoding, we mean the orientation and relative proximity of the genes within the circuit. In this work, we quantified the behaviour of an inducible, negatively autoregulated gene circuit arranged in different transcriptional configurations using the tetRA circuit from Tn10 as our basis....
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