Article

A fuzzy-to-ordered switch in the binding mode of the disordered regulator HigA2 mediates a ratio-sensing gene circuit

2026-06-02

Abstract excerpt

<title>Abstract</title> For globular transcription factors (TFs), the link between structure, sequence, and the output of the gene circuit is well established. In contrast, the mechanistic roles of intrinsically disordered regions (IDRs) in TFs and their connection to function remain less understood. Here, we investigate the <italic>higBA2</italic> toxin-antitoxin module from the human pathogen <italic>Vi...

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Literature Corpus work: 1df808c4-fc09-5cc8-be1d-d04430f19332
DOI: 10.21203/rs.3.rs-9629881/v1

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