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Article

Deubiquitylating enzymes and disease.

BMC biochemistry - 21 Oct 2008

Singhal Shweta, Taylor Matthew C, Baker Rohan T

Abstract excerpt

Deubiquitylating enzymes (DUBs) can hydrolyze a peptide, amide, ester or thiolester bond at the C-terminus of UBIQ (ubiquitin), including the post-translationally formed branched peptide bonds in mono- or multi-ubiquitylated conjugates. DUBs thus have the potential to regulate any UBIQ-mediated cellular process, the two best characterized being proteolysis and protein trafficking. Mammals contain some 80-90 DUBs...

Topics

Animals
Endopeptidases
Humans
Hydrolysis
Mutation
Neoplasms
Ubiquitin
von Hippel-Lindau Disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19007433
DOI: 10.1186/1471-2091-9-S1-S3
PMCID: PMC2582804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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