Article
The genetics of narcolepsy.
Annual review of genomics and human genetics - 1 Jan 2003
Chabas Dorothee, Taheri Shahrad, Renier Corinne, Mignot Emmanuel
Abstract excerpt
Human narcolepsy is a genetically complex disorder. Family studies indicate a 20-40 times increased risk of narcolepsy in first-degree relatives and twin studies suggest that nongenetic factors also play a role. The tight association between narcolepsy-cataplexy and the HLA allele DQB1*0602 suggests that narcolepsy has an autoimmune etiology. In recent years, extensive genetic studies in animals, using positional...
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