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Pyruvate kinase M in germ cells is essential for sperm motility and male fertility but not spermatogenesis

24 Oct 2023

Abstract excerpt

Male germ cells employ specific metabolic pathways throughout their developmental stages. In a previous study, we discovered heightened expression of pyruvate kinase M (PKM), a pivotal glycolytic enzyme, in spermatogonia and spermatids. To gain deeper insights into PKM's roles in spermatogenesis, sperm function, and male fertility, we engineered a conditional-knockout mouse model ( Pkm -vKO mice) to selectively...

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PMID: 37902871
DOI: 10.4103/aja202350

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