Article
Mamld1 knockdown reduces testosterone production and Cyp17a1 expression in mouse Leydig tumor cells.
PloS one - 29 Apr 2011
Nakamura Michiko, Fukami Maki, Sugawa Fumihiro, Miyado Mami, Nonomura Katsuya, Ogata Tsutomu
Abstract excerpt
BACKGROUND: MAMLD1 is known to be a causative gene for hypospadias. Although previous studies have indicated that MAMLD1 mutations result in hypospadias primarily because of compromised testosterone production around the critical period for fetal sex development, the underlying mechanism(s) remains to be clarified. Furthermore, although functional studies have indicated a transactivation function of MAMLD1 for...
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