Article
[Forward genetic screening for zebrafish mutants defective in myelopoiesis].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University - 1 Jun 2010
Dai Zhao-xia, Yan Guang, Chen Ying-hua, Liu Wei, Huo Zhong-jun, Wen Zong-hua, Liu Jing, Wang Kun, Huang Zhi-bing, Ma Ning, Chen Xiao-hui, Ma Ping-yun, Luo Wei-hao, Zhao Ying, Fan Shu, Huang Hong-hui, Wen Zi-long, Zhang Wen-qing
Abstract excerpt
OBJECTIVE: To identify zebrafish mutants with myelopoiesis defects by ENU mutagenesis and large-scale forward genetic screening. METHODS: Male zebrafish were mutagenized with N-ethyl N-nitrosourea to induce mutations in the spermatogonial cells to generate the founders, which were outcrossed with AB to raise F1 fish. The F1 fish from different founders were mated to generate the F2 families. The F3 embryos from...
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