The association between the SNP rs763110 and the risk of gynecological cancer: a meta-analysis.

doi:10.1016/j.biopha.2014.11.022

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Article

The association between the SNP rs763110 and the risk of gynecological cancer: a meta-analysis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Feb 2015

Zhou Lingling, Zhang Gang, Zhou Xiaoguang, Li Jun

Abstract excerpt

FAS and FAS ligand (FASL) are the principal genes of the apoptosis pathway, which play a vital role in the etiology of various gynecological cancers. Studies have revealed that polymorphism of FASL promoter -844C>T (rs763110) influences FASL transcription process, which involving in cancer risk. Moreover, estrogen has been proved to trigger T-cell apoptosis by up-regulating FAS/FASL system in cancer cells....

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PMID: 25661359
DOI: 10.1016/j.biopha.2014.11.022

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